Epithelial-mesenchymal transition during extravillous trophoblast differentiation
نویسندگان
چکیده
منابع مشابه
Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition.
The transformation of cytotrophoblast (CTB) to extravillous trophoblast (EVT) is an essential process for placental implantation. EVT generated at the tips of the anchoring villi migrate away from the placenta and invade the endometrium and maternal spiral arteries, where they modulate maternal immune responses and remodel the arteries into high-volume conduits to facilitate uteroplacental bloo...
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At the tips of anchoring villi, cytotrophoblast (CTB) proliferation leads to a process of multilayering in which cells lose their attachment to the villous basement membrane and develop into columns, within which they adhere to one another using desmosomes, with associated intermediate filament bundles. Non-desmosomal cadherins, tight junction proteins and other adhesion molecules are also pres...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2016
ISSN: 1933-6918,1933-6926
DOI: 10.1080/19336918.2016.1170258